HRID549536

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID222

Ammonia gas

H3N

反应SMILES：COc1ccc(F)cc1C(C)(C)CC(O)(CNc1cc(C)cc2c1cnn2-c1cccc(C(=O)N[C@H](CO)C(=O)O)c1)C(F)(F)F

HCID57672647

未命名化合物

PRODUCTS

产物

反应SMILES：COc1ccc(F)cc1C(C)(C)CC(O)(CNc1cc(C)cc2c1cnn2-c1cccc(C(=O)N[C@H](CO)C(N)=O)c1)C(F)(F)F

HCID24782919

未命名化合物

PROCEDURE

实验过程

Prepared similarly to Example 14 from N-{[3-(4-{[4-[5-fluoro-2-(methyloxy)phenyl]-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl]amino}-6-methyl-1H-indazol-1-yl)phenyl]carbonyl}-D-serine and ammonia.

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-37b641ffde5041f39dc4c8918c670b7c
来源数据集: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US07943651B2
来源说明: uspto-grants-2011_05

反应SMILES

[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:45][CH3:46])=[C:6]([C:8]([CH3:44])([CH3:43])[CH2:9][C:10]([OH:42])([C:38]([F:41])([F:40])[F:39])[CH2:11][NH:12][C:13]2[CH:21]=[C:20]([CH3:22])[CH:19]=[C:18]3[C:14]=2[CH:15]=[N:16][N:17]3[C:23]2[CH:24]=[C:25]([C:29]([NH:31][C@@H:32]([C:35]([OH:37])=O)[CH2:33][OH:34])=[O:30])[CH:26]=[CH:27][CH:28]=2)[CH:7]=1.[NH3:47]>>[NH2:47][C:35](=[O:37])[C@H:32]([NH:31][C:29](=[O:30])[C:25]1[CH:26]=[CH:27][CH:28]=[C:23]([N:17]2[C:18]3[C:14](=[C:13]([NH:12][CH2:11][C:10]([OH:42])([C:38]([F:41])([F:40])[F:39])[CH2:9][C:8]([C:6]4[CH:7]=[C:2]([F:1])[CH:3]=[CH:4][C:5]=4[O:45][CH3:46])([CH3:44])[CH3:43])[CH:21]=[C:20]([CH3:22])[CH:19]=3)[CH:15]=[N:16]2)[CH:24]=1)[CH2:33][OH:34]