Hydrochloric Acid → HCID 178478949, compound

HRID 54959Notes

Reaction equation

HRID 54959 reaction equation
[NH2:1][C:2]1[NH:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][C:10]([F:13])=[CH:9][CH:8]=2)[C:3]=1[C:14]1[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=1.[F:20][C:21]1[CH:26]=[CH:25][C:24]([C:27](=O)[CH:28]([C:30]2[CH:35]=[CH:34][C:33]([F:36])=[CH:32][CH:31]=2)O)=[CH:23][CH:22]=1.[ClH:38]>C(O)C>[ClH:38].[F:20][C:21]1[CH:22]=[CH:23][C:24]([C:27]2[NH:1][C:2]3[N:6]([C:28]=2[C:30]2[CH:31]=[CH:32][C:33]([F:36])=[CH:34][CH:35]=2)[N:5]=[C:4]([C:7]2[CH:12]=[CH:11][C:10]([F:13])=[CH:9][CH:8]=2)[C:3]=3[C:14]2[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=2)=[CH:25][CH:26]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 1037861,2-Bis(4-fluorophenyl)-2-hydroxyethanoneHCID 178509109HCID 178509109, compound

Product 1

HCID 178478949HCID 178478949, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 5-amino-3-(4-fluorophenyl)-4-(pyridin-4-yl)pyrazole (100 mg), 1,2-bis-(4-fluorophenyl)-2-hydroxyethan-1-one (167 mg) and concentrated hydrochloric acid (1 ml) in ethanol was refluxed for 5 hours. The reaction mixture was concentrated in vacuo and the obtained crystalline was washed with hot ethanol to give 2,3,6-tris-(4-fluorophenyl)-7-(pyridin-4-yl)-1H-imidazo[1,2-b]pyrazole hydrochloride (50 mg).

Workup

  1. temperaturewas refluxed for 5 hours
  2. concentrationThe reaction mixture was concentrated in vacuo
  3. washthe obtained crystalline was washed with hot ethanol

Sources & evidence

ORD record
ord-71b201434b5e4e28b4a4334cff904e74
Source dataset
uspto-grants-1997_04
Patent number
US05624931

Reaction notes

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