Hydrochloric Acid → HCID 66796966, compound

HRID 549762Notes

Reaction equation

HRID 549762 reaction equation
[ClH:1].O1CCOCC1.OC(C(F)(F)F)=O.[C:15]1([S:21]([N:24]2[CH2:29][CH2:28][N:27](C(OC(C)(C)C)=O)[CH2:26][CH:25]2[CH2:37][O:38][C:39]2[CH:40]=[N:41][CH:42]=[CH:43][CH:44]=2)(=[O:23])=[O:22])[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[ClH:1].[ClH:1].[C:15]1([S:21]([N:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH:25]2[CH2:37][O:38][C:39]2[CH:40]=[N:41][CH:42]=[CH:43][CH:44]=2)(=[O:22])=[O:23])[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 131728878tert-butyl 4-(phenylsulfonyl)-3-((pyridin-3-yloxy)methyl)piperazine-1-carboxylate TFA salt

Product 1

HCID 66796966HCID 66796966, compoundYield 91%

Procedure

4 M HCl in 1,4-dioxane (6 mL, 24 mmol) was added to tert-butyl 4-(phenylsulfonyl)-3-((pyridin-3-yloxy)methyl)piperazine-1-carboxylate TFA salt (122 mg, 0.223 mmol). After 1 h, the reaction mixture was concentrated under reduced pressure, yielding 82.4 mg (91%) of the desired product as a yellow solid. LC-MS: RT=3.71 min, [M+H]+=334.1.

Workup

  1. concentrationthe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-d903309f8dce4fadbd558b09ae06c32a
Source dataset
uspto-grants-2011_05
Patent number
US07943622B2

Reaction notes

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