反应详情

温度

35 °C

To a solution of 2-methyl-4-(4-methylthiophenyl)-1-(2H)-phthalazinone (14.15 g, 0.05 mol) in acetic acid (330 mL) was added 30% H2O2 (22 mL). The mixture was heated to 35° C. overnight, additional 30% H2O2 (10 mL) was added and the mixture was stirred at 35° C. for 2 hours and finally one final portion of 30% H2O2 (10 mL) was added and the mixture was stirred for another 2 hours at 35° C. The reaction mixture was poured into water (1 L)/ice and the solid thus obtained was collected by filtration, washed with water, then ether, and then was dried to afford 14.6 g (93%) of 2-methyl-4-(4-methylsulfonylphenyl)-1-(2H)-phthalazinone as a pale yellow solid, m.p. 218°-220° C. when recrystallized from ethanol/chloroform (2×).

1. stirringthe mixture was stirred for another 2 hours at 35° C
2. customthe solid thus obtained
3. filtrationwas collected by filtration
4. washwashed with water
5. dry with materialether, and then was dried