反应详情

5-Bromo-2-methylbenzo[b]thiophene (8.0 g, 35.2 mmol; prepared according to J. Med. Chem. 1986, 29, 1643) was dissolved in acetic acid (200 mL); 30% hydrogen peroxide (50 mL) was added and the mixture was refluxed for 4 h. Water (500 mL) was added and the mixture was extracted with benzene (300 mL). The organic layer was evaporated in vacuo and the residue was purified by column chromatography (silica gel Fluka 60, benzene) affording 5-bromo-2-methylbenzo[b]thiophene-1,1-dioxide.

1. temperaturethe mixture was refluxed for 4 h
2. extractionthe mixture was extracted with benzene (300 mL)
3. customThe organic layer was evaporated in vacuo
4. customthe residue was purified by column chromatography (silica gel Fluka 60, benzene)