Hydrochloric Acid → HCID 67158336, compound

Participants

Reaction Steps

A solution of tert-butyl 3-({4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}carbonyl)piperidine-1-carboxylate (1.5 g) in dichloromethane (10 ml) was stirred at room temperature. A 4M solution HCl in dioxane (20 ml) was added and the mixture was stirred for 30 minutes. The mixture was filtered and washed with dichloromethane and then diethyl ether. This gave 1-(piperidin-3-ylcarbonyl)-4-[3-(trifluoromethyl)phenyl]piperazine hydrochloride as a white solid (1.3 g).

Provenance & Evidence