Hydrochloric Acid → HCID 67158336, compound

HRID 549931Notes

Reaction equation

HRID 549931 reaction equation
[F:1][C:2]([F:31])([F:30])[C:3]1[CH:4]=[C:5]([N:9]2[CH2:14][CH2:13][N:12]([C:15]([CH:17]3[CH2:22][CH2:21][CH2:20][N:19](C(OC(C)(C)C)=O)[CH2:18]3)=[O:16])[CH2:11][CH2:10]2)[CH:6]=[CH:7][CH:8]=1.[ClH:32]>ClCCl.O1CCOCC1>[ClH:32].[NH:19]1[CH2:20][CH2:21][CH2:22][CH:17]([C:15]([N:12]2[CH2:13][CH2:14][N:9]([C:5]3[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:31])([F:1])[F:30])[CH:4]=3)[CH2:10][CH2:11]2)=[O:16])[CH2:18]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 24513873HCID 24513873, compound

Product 1

HCID 67158336HCID 67158336, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

A solution of tert-butyl 3-({4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}carbonyl)piperidine-1-carboxylate (1.5 g) in dichloromethane (10 ml) was stirred at room temperature. A 4M solution HCl in dioxane (20 ml) was added and the mixture was stirred for 30 minutes. The mixture was filtered and washed with dichloromethane and then diethyl ether. This gave 1-(piperidin-3-ylcarbonyl)-4-[3-(trifluoromethyl)phenyl]piperazine hydrochloride as a white solid (1.3 g).

Workup

  1. filtrationThe mixture was filtered
  2. washwashed with dichloromethane

Sources & evidence

ORD record
ord-69b1b180c08d4239984533ac627510ba
Source dataset
uspto-grants-2011_05
Patent number
US07943768B2

Reaction notes

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