HuagongsheHuagongshe Chemistry Print Report · For research reference only
(5-chloro-1-methyl-1H-pyrazol-4-yl)acetic acid → 2-(5-Chloro-1-methyl-1H-pyrazol-4-yl)-1-{4-[4-(2-phenylethyl)-1,3-thiazol-2-yl]piperidin-1-yl}ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (5-chloro-1-methyl-1H-pyrazol-4-yl)acetic acid | HCID 67156609 | — |
| Reactant | 4-[4-(2-Phenylethyl)-1,3-thiazol-2-yl]piperidine hydrochloride | HCID 67156883 | — |
| Product | 2-(5-Chloro-1-methyl-1H-pyrazol-4-yl)-1-{4-[4-(2-phenylethyl)-1,3-thiazol-2-yl]piperidin-1-yl}ethanone | HCID 67156890 | — |
Reaction Steps
4-[4-(2-Phenylethyl)-1,3-thiazol-2-yl]piperidine hydrochloride (II-1, 280 mg) is reacted analogously to Example I-63 with (5-chloro-1-methyl-1H-pyrazol-4-yl)acetic acid (174 mg). After chromatographic purification, this gives 2-(5-chloro-1-methyl-1H-pyrazol-4-yl)-1-{4-[4-(2-phenylethyl)-1,3-thiazol-2-yl]piperidin-1-yl}ethanone (89 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07943774B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-0ae4f34ef8e5466aadadb5244d117bbe |
| Source note | uspto-grants-2011_05 |