Picolyl chloride hydrochloride → HCID 11441018, compound

HRID 550066Notes

Reaction equation

HRID 550066 reaction equation
[CH:1]1([NH:4][C:5]([C:7]2[CH:8]=[CH:9][C:10]([CH3:23])=[C:11]([NH:13][C:14]([C:16]3[CH:21]=[CH:20][C:19]([OH:22])=[CH:18][N:17]=3)=[O:15])[CH:12]=2)=[O:6])[CH2:3][CH2:2]1.Cl.Cl[CH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][N:28]=1>>[CH:1]1([NH:4][C:5]([C:7]2[CH:8]=[CH:9][C:10]([CH3:23])=[C:11]([NH:13][C:14]([C:16]3[CH:21]=[CH:20][C:19]([O:22][CH2:26][C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][N:28]=4)=[CH:18][N:17]=3)=[O:15])[CH:12]=2)=[O:6])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 23392Picolyl chloride hydrochlorideHCID 66631124HCID 66631124, compound

Product 1

HCID 11441018HCID 11441018, compound

Procedure

The title compound was prepared from N-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}-5 -hydroxypyridine-2-carboxamide and 2-chloromethyl-pyridine hydrochloride according to the method described for Example 4; NMR Spectrum: (DMSOd6) 0.58 (m, 2H), 0.69 (m, 2H), 2.32 (s, 3H), 2.86 (m, 1H), 5.40 (s, 2H), 7.33 (m, 1H), 7.39 (m, 1H), 7.58 (m, 2H), 7.72 (m, 1H), 7.88 (m, 1H), 8.13 (m, 1H), 8.21 (m, 1H), 8.36 (m, 1H), 8.51 (m, 1H), 8.61 (m, 1H), 10.14 (s, 11H); Mass Spectrum: M+H+ 403.

Sources & evidence

ORD record
ord-1962a4855f0c4145bb1bf1dfdb065781
Source dataset
uspto-grants-2011_05
Patent number
US07943776B2

Reaction notes

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