Hydrogen Bromide → HCID 66630822, compound

HRID 550083Notes

Reaction equation

[CH:1]1([NH:4][C:5]([C:7]2[CH:8]=[CH:9][C:10]([CH3:31])=[C:11]([NH:13][C:14](=[O:30])[C:15]3[CH:20]=[CH:19][C:18]([O:21][CH2:22][C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][N:24]=4)=[C:17]([F:29])[CH:16]=3)[CH:12]=2)=[O:6])[CH2:3][CH2:2]1.[BrH:32]>>[BrH:32].[CH:1]1([NH:4][C:5]([C:7]2[CH:8]=[CH:9][C:10]([CH3:31])=[C:11]([NH:13][C:14](=[O:30])[C:15]3[CH:20]=[CH:19][C:18]([O:21][CH2:22][C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][N:24]=4)=[C:17]([F:29])[CH:16]=3)[CH:12]=2)=[O:6])[CH2:2][CH2:3]1

Participants

Reactant 2

HCID 260Hydrogen Bromide

HCID 11154338HCID 11154338, compound

Product 1

HCID 66630822HCID 66630822, compound

Procedure

Using an analogous procedure to that described in Example 36, N-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}-3-fluoro-4-(pyridin-2-ylmethoxy)benzamide was reacted with hydrobromic acid to give the title compound; NMR Spectrum: (DMSOd6) 0.57 (m, 2H), 0.68 (m, 2H), 2.25 (s, 3H), 2.86 (m, 1H), 5.48 (s, 2H), 7.32 (m, 1H), 7.42 (m, 1H), 7.64 (m, 2H), 7.82 (m, 4H), 8.17 (m, 1H), 8.37 (m, 1H), 8.75 (m, 1H), 9.92 (s, 1H); Mass Spectrum: M+H+ 420.

Sources & evidence

ORD record: ord-0e2d78d43c2b4ccfb61758ea771795c4
Source dataset: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07943776B2

Reaction notes

Loading…