Hydrogen Bromide → HCID 66631091, compound

HRID 550086Notes

Reaction equation

[CH:1]1([NH:4][C:5]([C:7]2[CH:8]=[CH:9][C:10]([CH3:30])=[C:11]([NH:13][C:14]([C:16]3[CH:21]=[CH:20][C:19]([O:22][CH2:23][C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][N:25]=4)=[CH:18][N:17]=3)=[O:15])[CH:12]=2)=[O:6])[CH2:3][CH2:2]1.[BrH:31]>>[BrH:31].[CH:1]1([NH:4][C:5]([C:7]2[CH:8]=[CH:9][C:10]([CH3:30])=[C:11]([NH:13][C:14]([C:16]3[CH:21]=[CH:20][C:19]([O:22][CH2:23][C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][N:25]=4)=[CH:18][N:17]=3)=[O:15])[CH:12]=2)=[O:6])[CH2:3][CH2:2]1

Participants

Reactant 2

HCID 260Hydrogen Bromide

HCID 11441018HCID 11441018, compound

Product 1

HCID 66631091HCID 66631091, compound

Procedure

Using an analogous procedure to that described in Example 36, N-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}-5 -(pyridin-2-ylmethoxy)pyridine-2-carboxamide was reacted with hydrobromic acid to give the title compound; NMR Spectrum: (DMSOd6) 0.58 (m, 2H), 0.69 (m, 2H), 2.32 (s, 3H), 2.86 (m, 1H), 5.49 (s, 2H), 7.33 (m, 1H), 7.58 (m, 1H), 7.76 (m, 2H), 7.95 (m, 1H), 8.15 (m, 2H), 8.34 (m, 2H), 8.53 (m, 1H), 8.82 (m, 1H), 10.13 (s, 1H); Mass Spectrum: M+H+ 403.

Sources & evidence

ORD record: ord-dd4a844f0c144aebada6ee434c1077a2
Source dataset: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07943776B2

Reaction notes

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