Benzyl chloroformate → HCID 178523389, compound

HRID 550123Notes

Reaction equation

HRID 550123 reaction equation
[NH2:1][CH2:2][C@H:3]1[CH2:8][CH2:7][C@H:6]([C:9]([OH:11])=[O:10])[CH2:5][CH2:4]1.[OH-].[Na+].Cl[C:15]([O:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:16]>>[CH2:18]([O:17][C:15]([NH:1][CH2:2][C@H:3]1[CH2:4][CH2:5][C@H:6]([C:9]([OH:11])=[O:10])[CH2:7][CH2:8]1)=[O:16])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

4

Reactant 3

HCID 10387Benzyl chloroformateHCID 14798Sodium HydroxideHCID 178511262HCID 178511262, compound

Product 1

HCID 178523389HCID 178523389, compound

Procedure

trans-4-(Aminomethyl)cyclohexanecarboxylic acid (10.00 g, 0.06361 mol), in a 10% aq solution of NaOH (5.60 g in 55 mL) was cooled to 0° C. and treated over 15 min with vigorous stirring, with benzyl chloroformate (11 mL, 0.076 mol). After one hour the solution was acidified (1M

Sources & evidence

ORD record
ord-b2cfde7b49d14f6b8139f6797ae8543e
Source dataset
uspto-grants-2011_05
Patent number
US07943767B2

Reaction notes

Loading…