反应详情

Cool 6-benzyloxynaphthalene-2-carboxylic acid methyl ester (5.75 g, 19.67 mmol) in THF (115 mL) to about 0° C. and treat the solution dropwise with ethyl magnesium bromide (23.0 mL, 69.0 mmol, 3.0 M in ether). Allow the reaction to warm to RT and stir it for 3 h. Quench with water and concentrate. Dissolve the crude residue in CH2CL2 (200 mL), wash twice with brine, dry over Na2SO4 and filter. Concentrate the filtrate to give the title compound as a yellow solid (6.0 g, 95%). MS (ES) m/e 321 (M+1).

1. customthe reaction
2. customQuench with water
3. concentrationconcentrate
4. dissolutionDissolve the crude residue in CH2CL2 (200 mL)
5. washwash twice with brine
6. dry with materialdry over Na2SO4
7. filtrationfilter
8. concentrationConcentrate the filtrate