反应详情

温度

55 °C

Treat a solution of 6-{1-[4-(3,3-Dimethyl-2-oxobutoxy)-3-methylphenyl]-1-ethylpropyl}-naphthalene-2-carboxylic acid methyl ester (0.53 g, 1.15 mmol) in THF (8 mL) and MeOH (16 mL) with 2N NaOH (2.9 mL, 5.8 mmol) and heat at 55° C. for 16 h. Concentrate the reaction mixture. Dilute the residue with in EtOAc (50 mL) and water (25 mL) and acidify the resulting mixture to pH 1 using 1N HCl. Discard the aqueous layer and wash the organic layer with brine, Dry the organic layer over Na2SO4, filter, and concentrate the filtrate to give the title compound as a yellow solid (0.45 g, 87%). MS (ES) m/e 447 (M+1).

1. concentrationConcentrate the reaction mixture
2. additionDilute the residue with in EtOAc (50 mL) and water (25 mL)
3. washwash the organic layer with brine
4. dry with materialDry the organic layer over Na2SO4
5. filtrationfilter
6. concentrationconcentrate the filtrate