HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → HCID 57871401, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | Dichloromethane ethylacetate | HCID 21226138 | — |
| Reactant | HCID 57871402 | HCID 57871402 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 57871401 | HCID 57871401 | 8% |
Reaction Steps
Following the procedure described in Example 2; treat 6-{1-[4-(3,3-dimethyl-1-ethyl-2-oxobutoxy)-3-methylphenyl]-1-ethylpropyl}naphthalene-2-carboxylic acid methyl ester with NaBH4 in THF at 0 C. Chromatograph the residue (CH2Cl2 to 2% EtOAc/CH2Cl2) to give diastereomeric isomer pair 1 of the title compound as a glassy foam (1.004 g, 77%) and diastereomeric isomer pair 2 of the title compound as a glassy foam (102 mg, 8%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07943795B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-63fe3a7be03e4497b572418d51b72d9c |
| Source note | uspto-grants-2011_05 |