HRID550222

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6344

Dichloromethane

CH2Cl2

HCID4311764

Sodium borohydride (Na(BH4))

H4BNa

HCID21226138

未命名化合物

结构：CCC(Oc1ccc(C(CC)(CC)c2ccc3cc(C(=O)OC)ccc3c2)cc1C)C(=O)C(C)(C)C

HCID57871402

未命名化合物

PRODUCTS

生成物

HCID57871401

未命名化合物

收率 8%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

Following the procedure described in Example 2; treat 6-{1-[4-(3,3-dimethyl-1-ethyl-2-oxobutoxy)-3-methylphenyl]-1-ethylpropyl}naphthalene-2-carboxylic acid methyl ester with NaBH4 in THF at 0 C. Chromatograph the residue (CH2Cl2 to 2% EtOAc/CH2Cl2) to give diastereomeric isomer pair 1 of the title compound as a glassy foam (1.004 g, 77%) and diastereomeric isomer pair 2 of the title compound as a glassy foam (102 mg, 8%).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-63fe3a7be03e4497b572418d51b72d9c
来源数据集: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07943795B2
来源说明: uspto-grants-2011_05

反应 SMILES

[CH3:1][O:2][C:3]([C:5]1[CH:14]=[CH:13][C:12]2[C:7](=[CH:8][CH:9]=[C:10]([C:15]([C:20]3[CH:25]=[CH:24][C:23]([O:26][CH:27]([CH2:34][CH3:35])[C:28](=[O:33])[C:29]([CH3:32])([CH3:31])[CH3:30])=[C:22]([CH3:36])[CH:21]=3)([CH2:18][CH3:19])[CH2:16][CH3:17])[CH:11]=2)[CH:6]=1)=[O:4].[BH4-].[Na+].C(Cl)Cl.CCOC(C)=O.C(Cl)Cl>C1COCC1>[CH3:1][O:2][C:3]([C:5]1[CH:14]=[CH:13][C:12]2[C:7](=[CH:8][CH:9]=[C:10]([C:15]([CH2:16][CH3:17])([C:20]3[CH:25]=[CH:24][C:23]([O:26][CH:27]([CH2:34][CH3:35])[CH:28]([OH:33])[C:29]([CH3:30])([CH3:31])[CH3:32])=[C:22]([CH3:36])[CH:21]=3)[CH2:18][CH3:19])[CH:11]=2)[CH:6]=1)=[O:4]