HRID550337

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：N[C@H]1C(O)O[C@H](CO)[C@H](O)[C@@H]1O

HCID24154

Galactosamine

C6H13NO5

结构：CN1c2c(nc(N)[nH]c2=O)NC[C@H]1CNc1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1

HCID135430866

未命名化合物

PRODUCTS

生成物

结构：CN1c2c(nc(N)[nH]c2=O)NC[C@H]1CNc1ccc(C(=O)N[C@@H](CCC(=O)[O-])C(=O)O)cc1.N[C@H]1C(O)O[C@H](CO)[C@H](O)[C@@H]1O

HCID136356797

未命名化合物

收率 136.8%

PROCEDURE

实验过程

4.60 g (10 mmol) of 5-methyl-(6R,S)-tetrahydrofolic acid were added portion-wise and completely dissolved in 30 ml of an aqueous solution of D-galactosamine (3.58 g, 20 mmol) stirred under nitrogen. The resulting solution (pH 6.53) was freeze-dried, obtaining 8.72 g of the title product.

WORKUP

后处理

dry with materialThe resulting solution (pH 6.53) was freeze-dried

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-caa93320f62e46c8bd63c1ad2c7e3d23
来源数据集: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07947662B2
来源说明: uspto-grants-2011_05

反应 SMILES

[CH3:1][N:2]1[C@H:11]([CH2:12][NH:13][C:14]2[CH:31]=[CH:30][C:17]([C:18](=[O:29])[NH:19][C@H:20]([C:26]([OH:28])=[O:27])[CH2:21][CH2:22][C:23]([OH:25])=[O:24])=[CH:16][CH:15]=2)[CH2:10][NH:9][C:8]2[N:7]=[C:6]([NH2:32])[NH:5][C:4](=[O:33])[C:3]1=2.[OH:34][CH:35]1[O:43][C@H:42]([CH2:44][OH:45])[C@H:40]([OH:41])[C@H:38]([OH:39])[C@H:36]1[NH2:37]>>[OH:34][CH:35]1[O:43][C@H:42]([CH2:44][OH:45])[C@H:40]([OH:41])[C@H:38]([OH:39])[C@H:36]1[NH2:37].[CH3:1][N:2]1[C@H:11]([CH2:12][NH:13][C:14]2[CH:15]=[CH:16][C:17]([C:18](=[O:29])[NH:19][C@H:20]([C:26]([OH:28])=[O:27])[CH2:21][CH2:22][C:23]([O-:25])=[O:24])=[CH:30][CH:31]=2)[CH2:10][NH:9][C:8]2[N:7]=[C:6]([NH2:32])[NH:5][C:4](=[O:33])[C:3]1=2