反应详情

The procedure described in Example 23 was repeated using 3-(2-chloroethoxy)-N-{3-chloro-4-[(6-methylpyridin-3-yl)oxy]phenyl}-1H-pyrazolo[3,4-d]pyrimidin-4-amine and N-methylpiperazine to give the title compound in 42% yield; NMR Spectrum: 2.11 (s, 3H), 2.28 (br s, 4H), 2.45 (s, 3H), 2.50 (hidden by DMSO, 4H), 2.80 (t, 2H), 4.44 (t, 2H), 7.20 (d, 1H), 7.26 (br s, 2H), 7.72 (d, 1H), 8.11 (s, 1H), 8.20 (s, 1H), 8.36 (s, 1H), 8.59 (br s, 1H); Mass Spectrum: 495 (MH+).