Glycolic Acid → HCID 11720009, compound

HRID 550493Notes

Reaction equation

HRID 550493 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:16][C:17]2[N:22]=[CH:21][N:20]=[C:19]3[NH:23][N:24]=[C:25]([O:26][CH2:27][CH2:28][NH:29][CH3:30])[C:18]=23)[CH:5]=[CH:6][C:7]=1[O:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][N:11]=1.[C:31]([OH:35])(=O)[CH2:32][OH:33]>>[Cl:1][C:2]1[CH:3]=[C:4]([NH:16][C:17]2[N:22]=[CH:21][N:20]=[C:19]3[NH:23][N:24]=[C:25]([O:26][CH2:27][CH2:28][N:29]([CH3:30])[C:31](=[O:35])[CH2:32][OH:33])[C:18]=23)[CH:5]=[CH:6][C:7]=1[O:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][N:11]=1

Participants

3

Reactant 2

HCID 757Glycolic AcidHCID 11597061HCID 11597061, compound

Product 1

HCID 11720009HCID 11720009, compoundYield 100%

Procedure

The procedure described in Example 85 was repeated using N-[3-chloro-4-(pyridiN-2-ylmethoxy)phenyl]-3-[2-(methylamino)ethoxy]-1H-pyrazolo[3,4-d]pyrimidin-4-amine (prepared as described in Example 24) and glycolic acid to give the title compound in 100% yield; Mass Spectrum: 483.8 (M+/retention time 1.30 minutes).

Sources & evidence

ORD record
ord-b3e1cf05f7c34c5cac4995f56ea86077
Source dataset
uspto-grants-2011_05
Patent number
US07947676B2

Reaction notes

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