Ethyl bromoacetate → HCID 22923401, compound

HRID 55050Notes

Reaction equation

[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[N:8]=[CH:7][N:6]=[C:5]2[N:14]1[CH2:19][CH2:18][CH:17]([N:20]2[C:29](=[O:30])[C:28]3[C:23](=[CH:24][CH:25]=[C:26]([CH3:31])[CH:27]=3)[N:22]([CH3:32])[C:21]2=[O:33])[CH2:16][CH2:15]1.Br[CH2:35][C:36]([O:38][CH2:39][CH3:40])=[O:37]>>[CH2:39]([O:38][C:36]([CH2:35][O:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[N:8]=[CH:7][N:6]=[C:5]2[N:14]1[CH2:19][CH2:18][CH:17]([N:20]2[C:29](=[O:30])[C:28]3[C:23](=[CH:24][CH:25]=[C:26]([CH3:31])[CH:27]=3)[N:22]([CH3:32])[C:21]2=[O:33])[CH2:16][CH2:15]1)=[O:37])[CH3:40]

Participants

Reactant 2

HCID 7748Ethyl bromoacetate

HCID 22923375HCID 22923375, compound

Product 1

HCID 22923401HCID 22923401, compoundYield 54%

Procedure

The procedure similar to that described in Example 1 was repeated, except that 500.0 mg (1.12 mmol) of Compound 90 obtained in Example 80 was used in place of Compound 24 and ethyl bromoacetate was used in place of methyl iodide. As a result, 323.3 mg (yield: 54%) of Compound 94 was obtained as white crystals.

Sources & evidence

ORD record: ord-ea1aef109b224d07bf29d29247c6c4f6
Source dataset: uspto-grants-1997_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05624926

Reaction notes

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