Hydrazine hydrate (1:1) → Pyridazine-4-carbohydrazide

HRID 550529Notes

Reaction equation

HRID 550529 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7]([O:9]C)=O)=[CH:3][N:2]=1.O.[NH2:12][NH2:13]>CO>[N:1]1[CH:6]=[CH:5][C:4]([C:7]([NH:12][NH2:13])=[O:9])=[CH:3][N:2]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 12439252Methyl pyridazine-4-carboxylate

Product 1

HCID 45084063Pyridazine-4-carbohydrazideYield 98.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of methyl 4-pyridazinecarboxylate (400 mg, 2.9 mmol) in MeOH (5 ml) was added hydrazine monohydrate (23 mmol). The solution was heated to reflux for 12 h. Volatiles were evaporated in vacuo to give 395 mg of the title compound as a yellow pale foam, which was used without further purification.

Workup

  1. temperatureThe solution was heated
  2. temperatureto reflux for 12 h
  3. customVolatiles were evaporated in vacuo

Sources & evidence

ORD record
ord-f2c703a19ce148b9a847c42d4312d49e
Source dataset
uspto-grants-2011_05
Patent number
US07947683B2

Reaction notes

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