2,4-Dimethylthiazole-5-carbohydrazide → 3-(2,4-dimethyl-1,3-thiazol-5-yl)-4-methyl-5-(4-penten-1-yl)-4H-1,2,4-triazole

HRID 550538Notes

Reaction equation

HRID 550538 reaction equation
[CH3:1][C:2]1[S:3][C:4]([C:8]([NH:10][NH2:11])=O)=[C:5]([CH3:7])[N:6]=1.Cl.[CH3:13][NH:14][C:15](=NC)[CH2:16][CH2:17][CH2:18][CH:19]=[CH2:20]>>[CH3:1][C:2]1[S:3][C:4]([C:8]2[N:14]([CH3:13])[C:15]([CH2:16][CH2:17][CH2:18][CH:19]=[CH2:20])=[N:11][N:10]=2)=[C:5]([CH3:7])[N:6]=1

Participants

3

Reactant 2

HCID 27436692,4-Dimethylthiazole-5-carbohydrazideHCID 86630240N,N'-dimethyl-5-hexenimidamide hydrochloride

Product 1

HCID 576919473-(2,4-dimethyl-1,3-thiazol-5-yl)-4-methyl-5-(4-penten-1-yl)-4H-1,2,4-triazole

Procedure

The title compound was prepared in analogy to Preparation 11 in 0.17 g yield starting from 2,4-dimethyl-1,3-thiazole-5-carbohydrazide (0.50 g) and N,N′-dimethyl-5-hexenimidamide hydrochloride (0.51 g). MS (m/z): 263 [MH]+.

Workup

  1. customyield

Sources & evidence

ORD record
ord-82e1d6ae89a7460dada36acc64d5fcaf
Source dataset
uspto-grants-2011_05
Patent number
US07947683B2

Reaction notes

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