反应详情

温度

-78 °C

To a solution of diisopropilamide (7.6 ml) in THF (12 ml) was added drop by drop n-butil lithium (2.5M in hexane, 21.6 ml) at −78° C. After stirring the reaction mixture at −78° C. for 30 minutes, a solution of methyl isobutyrate (5 g) in THF (12 ml) was added in 10 minutes and the mixture stirred at −78° C. for 1 h. A solution of allyl bromide (4.7 ml) in THF (12 ml) was dropped into the mixture reaction and it was stirred at −78° C. for 1 h. After adding some drop of water, volatiles were evaporated in vacuo, the crude dissolved in ethyl acetate, washed with water and dried over Na2SO4. After filtration volatiles were evaporated in vacuo to give 1.8 g of the title compound as a yellow pale liquid, which was used without further purification.

1. stirringthe mixture stirred at −78° C. for 1 h
2. stirringwas stirred at −78° C. for 1 h
3. customwere evaporated in vacuo
4. dissolutionthe crude dissolved in ethyl acetate
5. washwashed with water
6. dry with materialdried over Na2SO4
7. filtrationAfter filtration volatiles
8. customwere evaporated in vacuo