反应详情

3-thiophenecarboxylic acid (2.0 g) was dissolved in MeOH (27 mL) and concentrated sulphuric acid (1.5 mL) was added. The reaction mixture was refluxed for 3 hours and 30 min., then concentrated under reduced pressure. A saturated NaHCO3 solution was added and the mixture was extracted with ethyl acetate. The organic phase was dried over Na2SO4 and concentrated in vacuo to give 1.98 g of the title compound as a colourless liquid which was used without further purification.

1. temperatureThe reaction mixture was refluxed for 3 hours and 30 min.
2. concentrationconcentrated under reduced pressure
3. additionA saturated NaHCO3 solution was added
4. extractionthe mixture was extracted with ethyl acetate
5. dry with materialThe organic phase was dried over Na2SO4
6. concentrationconcentrated in vacuo