4-Amino-2-methylpyridine → 3-Bromo-6-methyl-pyrazine-2-carboxylic acid (2-methyl-pyridin-4-yl)-amide

HRID 550579Notes

Reaction equation

HRID 550579 reaction equation
C(O[C:4]([C:6]1[C:11]([Br:12])=[N:10][CH:9]=[C:8]([CH3:13])[N:7]=1)=[O:5])C.[CH3:14][C:15]1[CH:20]=[C:19]([NH2:21])[CH:18]=[CH:17][N:16]=1>>[CH3:14][C:15]1[CH:20]=[C:19]([NH:21][C:4]([C:6]2[C:11]([Br:12])=[N:10][CH:9]=[C:8]([CH3:13])[N:7]=2)=[O:5])[CH:18]=[CH:17][N:16]=1

Participants

3

Reactant 2

HCID 7286704-Amino-2-methylpyridineHCID 86607488Ethyl 3-bromo-6-methylpyrazine-2-carboxylate

Product 1

HCID 866074893-Bromo-6-methyl-pyrazine-2-carboxylic acid (2-methyl-pyridin-4-yl)-amide

Procedure

The title compound, MS: m/e=307.2 (M+H+), was prepared in accordance with the general method of example 1, step 2 from 3-bromo-6-methyl-pyrazine-2-carboxylic acid ethyl ester and 2-methyl-pyridin-4-ylamine (Example B).

Sources & evidence

ORD record
ord-4bf2f76c29f3414c904d877894d37900
Source dataset
uspto-grants-2011_05
Patent number
US07947685B2

Reaction notes

Loading…