Hydrochloric Acid → HCID 11996464, compound

Participants

Reaction Steps

[3-(4-Methyl-thiazol-2-ylcarbamoyl)-pyrazin-2-yl]-pyridin-3-yl-carbamic acid tert-butyl ester (180 mg, 0.44 mmol) was dissolved in 5 ml ethyl acetate and 8M HCl in ethanol (2.2 ml, 17.6 mmol) was added. The reaction mixture was stirred for 3 hrs at room temperature and diluted then with 20 mL diisopropylether. The solid material was filtered off and dried at 50° C. and 15 mbar for 1 hr. The desired compound was obtained as a yellow solid (169 mg, 99%), MS: m/e=313.1 (M+H+).

Provenance & Evidence