Hydrochloric Acid → HCID 11996464, compound

HRID 550585Notes

Reaction equation

HRID 550585 reaction equation
C(OC(=O)[N:7]([C:14]1[C:19]([C:20](=[O:28])[NH:21][C:22]2[S:23][CH:24]=[C:25]([CH3:27])[N:26]=2)=[N:18][CH:17]=[CH:16][N:15]=1)[C:8]1[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=1)(C)(C)C.[ClH:30].C(O)C.C(OC(C)C)(C)C>C(OCC)(=O)C>[ClH:30].[ClH:30].[CH3:27][C:25]1[N:26]=[C:22]([NH:21][C:20]([C:19]2[C:14]([NH:7][C:8]3[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=3)=[N:15][CH:16]=[CH:17][N:18]=2)=[O:28])[S:23][CH:24]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 7914Diisopropyl EtherHCID 86607491HCID 86607491, compound

Product 1

HCID 11996464HCID 11996464, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

[3-(4-Methyl-thiazol-2-ylcarbamoyl)-pyrazin-2-yl]-pyridin-3-yl-carbamic acid tert-butyl ester (180 mg, 0.44 mmol) was dissolved in 5 ml ethyl acetate and 8M HCl in ethanol (2.2 ml, 17.6 mmol) was added. The reaction mixture was stirred for 3 hrs at room temperature and diluted then with 20 mL diisopropylether. The solid material was filtered off and dried at 50° C. and 15 mbar for 1 hr. The desired compound was obtained as a yellow solid (169 mg, 99%), MS: m/e=313.1 (M+H+).

Workup

  1. additiondiluted
  2. filtrationThe solid material was filtered off
  3. customdried at 50° C.
  4. wait15 mbar for 1 hr

Sources & evidence

ORD record
ord-b07b9c98d7f7438699b8fed5e8be59bb
Source dataset
uspto-grants-2011_05
Patent number
US07947685B2

Reaction notes

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