1,1-Dichloroethane → 1082916-60-6

HRID 550644Notes

Reaction equation

HRID 550644 reaction equation
[CH3:1][CH:2]([NH2:9])[CH2:3][C:4]1[S:5][CH:6]=[CH:7][CH:8]=1.ClC(Cl)C.Cl[C:15](Cl)([O:17]C(=O)OC(Cl)(Cl)Cl)Cl>>[N:9]([CH:2]([CH3:1])[CH2:3][C:4]1[S:5][CH:6]=[CH:7][CH:8]=1)=[C:15]=[O:17]

Participants

4

Reactant 3

HCID 63651,1-DichloroethaneHCID 94429TriphosgeneHCID 64841332-(2-Aminopropyl)thiophene

Product 1

HCID 217537131082916-60-6

Procedure

To a solution of 1-methyl-2-thiophen-2-ylethylamine (2 g, 14.2 mmol) in dichloroethane (30 ml) triethylamine (4.3 g, 42.6 mmol) and triphosgene (2.1 g, 7.1 mmol) were added. The reaction mixture stirred for 1 h and concentrated on rotary evaporator. Diethyl ether is added, and the resulting mixture is filtered. Ether solution is concentrated, and the resulting oil is used in the next step without purification.

Workup

  1. concentrationconcentrated on rotary evaporator
  2. additionDiethyl ether is added
  3. filtrationthe resulting mixture is filtered
  4. concentrationEther solution is concentrated
  5. customthe resulting oil is used in the next step without purification

Sources & evidence

ORD record
ord-82e2faa6969343389c7289014c68f1cb
Source dataset
uspto-grants-2011_05
Patent number
US07947689B2

Reaction notes

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