HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Chloro-4-isothiocyanato-2-(trifluoromethyl)benzene → 1-[4-(6-Methoxy-2-quinolylthio)phenyl]-3-(4-chloro-3-trifluoromethylphenyl)thiourea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Chloro-4-isothiocyanato-2-(trifluoromethyl)benzene | HCID 520026 | — |
| Reactant | 2-(4-Aminophenylthio)-6-methoxyquinoline | HCID 18971662 | — |
| Product | 1-[4-(6-Methoxy-2-quinolylthio)phenyl]-3-(4-chloro-3-trifluoromethylphenyl)thiourea | HCID 18971666 | 72% |
Reaction Steps
2-(4-aminophenylthio)-6-methoxyquinoline (15.0 moles, 4.2 g) and 4-chloro-3-trifluoromethylphenylisothiocyanate (15.0 mmoles, 3.6 g) were reacted according to procedure C to yield 5.6 g, 72% of the title compound. Mass Spec (FD) 519. Calculated for C24H17ClF3N3OS2 : C, 55.44; H, 3.30; N, 8.08. Found: C, 55.62; H, 3.43; N, 8.27.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05624937 |
| Source dataset | uspto-grants-1997_04 |
| ORD ID | ord-da1e76e58112450bab27c461d4f79611 |
| Source note | uspto-grants-1997_04 |