2-Bromomethyl-1,4-benzodioxane → HCID 67200928, compound

HRID 550713Notes

Reaction equation

HRID 550713 reaction equation
C([O:4][N:5]1[C:10](=[O:11])[C:9]2[S:12][CH:13]=[CH:14][C:8]=2[N:7]([CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18](Br)[CH:17]=2)[C:6]1=[O:23])C=C.BrCC1O[C:30]2[CH:32]=CC=[CH:35][C:29]=2OC1>>[OH:4][N:5]1[C:10](=[O:11])[C:9]2[S:12][CH:13]=[CH:14][C:8]=2[N:7]([CH2:15][C:16]2[CH:21]=[CH:20][C:19]3[C:18](=[CH:35][CH:29]=[CH:30][CH:32]=3)[CH:17]=2)[C:6]1=[O:23]

Participants

3

Reactant 2

HCID 983332-Bromomethyl-1,4-benzodioxaneHCID 67200730HCID 67200730, compound

Product 1

HCID 67200928HCID 67200928, compound

Procedure

3-Allyloxy-1-(3-bromo-benzyl)-1H-thieno[3,2-d]pyrimidine-2,4-dione was alkylated with 2-bromomethyl-2,3-dihydro-benzo[1,4]dioxine via general procedure B2. The crude intermediate was deprotected via general procedure D2. The final product was purified by mass triggered preparative HPLC. Electrospray MS: 333 (M+H); retention time: 2.05 min.

Workup

  1. customThe final product was purified by mass

Sources & evidence

ORD record
ord-8ff2a863543a44719583ab6d7ddf1529
Source dataset
uspto-grants-2011_05
Patent number
US07947691B2

Reaction notes

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