HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Acetylphenylboronic acid → 1-(3'-Acetyl-biphenyl-3-ylmethyl)-3-hydroxy-1H-thieno[3,2-d]pyrimidine-2,4-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Acetylphenylboronic acid | HCID 2734310 | — |
| Reactant | 1-(3-Bromo-benzyl)-3-hydroxy-1H-thieno[3,2-d]pyrimidine-2,4-dione | HCID 11544874 | — |
| Product | 1-(3'-Acetyl-biphenyl-3-ylmethyl)-3-hydroxy-1H-thieno[3,2-d]pyrimidine-2,4-dione | HCID 11625324 | — |
Reaction Steps
The title compound was prepared from 1-(3-Bromo-benzyl)-3-hydroxy-1H-thieno[3,2-d]pyrimidine-2,4-dione (from previous example) and 3-acetyl-phenyl boronic acid via general procedure C. The crude product was purified by mass-triggered preparative HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07947691B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-03124c44156d46deb71d34677b900e36 |
| Source note | uspto-grants-2011_05 |