Picolyl chloride hydrochloride → HCID 11666995, compound

HRID 550731Notes

Reaction equation

HRID 550731 reaction equation
COC1C=C(OC)C=CC=1C[O:6][N:7]1[C:12](=[O:13])[C:11]2[S:14][C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[C:10]=2[NH:9][C:8]1=[O:21].Cl.Cl[CH2:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][N:32]=1>>[OH:6][N:7]1[C:12](=[O:13])[C:11]2[S:14][C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[C:10]=2[N:9]([CH2:30][C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][N:32]=2)[C:8]1=[O:21]

Participants

3

Reactant 2

HCID 23392Picolyl chloride hydrochlorideHCID 672009343-(2,4-Dimethoxy-benzyloxy)-1H-benzo[4,5]thieno[3,2-d]pyrimidine-2,4-dione

Product 1

HCID 11666995HCID 11666995, compound

Procedure

Following general procedure B2 and D1, 3-(2,4-Dimethoxy-benzyloxy)-1H-benzo[4,5]thieno[3,2-d]pyrimidine-2,4-dione was alkylated with 2-chloromethylpyridine hydrochloride and subsequently deprotected to provide the title compound as a white solid.

Sources & evidence

ORD record
ord-4dc1c224f0834efdafca1242df6e226b
Source dataset
uspto-grants-2011_05
Patent number
US07947691B2

Reaction notes

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