4-Bromobenzyl bromide → HCID 11531150, compound

HRID 550745Notes

Reaction equation

HRID 550745 reaction equation
COC1C=C(OC)C=CC=1C[O:6][N:7]1[C:12](=[O:13])[C:11]2[O:14][C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[C:10]=2[NH:9][C:8]1=[O:21].[Br:28][C:29]1[CH:36]=[CH:35][C:32]([CH2:33]Br)=[CH:31][CH:30]=1>>[Br:28][C:29]1[CH:36]=[CH:35][C:32]([CH2:33][N:9]2[C:10]3[C:16]4[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=4[O:14][C:11]=3[C:12](=[O:13])[N:7]([OH:6])[C:8]2=[O:21])=[CH:31][CH:30]=1

Participants

3

Reactant 2

HCID 685274-Bromobenzyl bromideHCID 672018793-(2,4-Dimethoxy-benzyloxy)-1H-benzo[4,5]furo[3,2-d]pyrimidine-2,4-dione

Product 1

HCID 11531150HCID 11531150, compound

Procedure

Following general procedure B2 and D1, 3-(2,4-dimethoxy-benzyloxy)-1H-benzo[4,5]furo[3,2-d]pyrimidine-2,4-dione was alkylated with 4-bromobenzyl bromide and subsequently deprotected to provide the title compound as a white solid. 1H NMR (d6-DMSO, 300 MHz) δ 5.52 (s, 2H); 7.29-7.40 (m, 3H); 7.52 (d, J=8 Hz, 2H); 7.60 (dd, J=8 Hz, 1H); 7.75-7.81 (m, 2H); Ret. time=2.70 min., m/z=387.0.

Sources & evidence

ORD record
ord-5d584c60c73f425b8bdef04476d835ea
Source dataset
uspto-grants-2011_05
Patent number
US07947691B2

Reaction notes

Loading…