4-Chlorobutyramide → 2-Amino-6-aminomethylcarbonylamino-4-[2-(3-aminocarbonylpropoxy)phenyl]quinazoline

HRID 550773Notes

Reaction equation

[NH2:1][C:2]1[N:11]=[C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[OH:18])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([NH:19][C:20]([CH2:22][NH2:23])=[O:21])[CH:8]=2)[N:3]=1.Cl[CH2:25][CH2:26][CH2:27][C:28]([NH2:30])=[O:29]>>[NH2:1][C:2]1[N:11]=[C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[O:18][CH2:25][CH2:26][CH2:27][C:28]([NH2:30])=[O:29])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([NH:19][C:20]([CH2:22][NH2:23])=[O:21])[CH:8]=2)[N:3]=1

Participants

Reactant 2

HCID 755644-Chlorobutyramide

HCID 1362847542-Amino-6-aminomethylcarbonylamino-4-(2-hydroxyphenyl)quinazoline

Product 1

HCID 159484582-Amino-6-aminomethylcarbonylamino-4-[2-(3-aminocarbonylpropoxy)phenyl]quinazoline

Procedure

Analogous reaction of 2-amino-6-aminomethylcarbonylamino-4-(2-hydroxyphenyl)quinazoline with 4-chlorobutyramide gives the compound 2-amino-6-aminomethylcarbonylamino-4-[2-(3-aminocarbonylpropoxy)phenyl]quinazoline (“A61”).

Sources & evidence

ORD record: ord-e1db0196b8d44a4b9090ce38108986b8
Source dataset: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07947696B2

Reaction notes

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