Imatinib → Imatinib Mesylate

Participants

Reaction Steps

The solution in step-(a) may also be prepared by admixing imatinib base, methanesulfonic acid and the solvent medium to obtain a mixture; and heating the mixture to obtain a solution of imatinib mesylate. In one embodiment, the mixture is heated at a temperature of about 40° C. to about 110° C., and more preferably at about 50° C. to about 80° C.

Provenance & Evidence