HRID550780

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Nc1nccc(-c2cccnc2)n1

HCID5291

Imatinib

C29H31N7O

HCID6395

Methanesulfonic acid

CH4O3S

PRODUCTS

生成物

结构：CS(=O)(=O)O.Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Nc1nccc(-c2cccnc2)n1

HCID123596

Imatinib mesylate

C30H35N7O4S

PROCEDURE

实验过程

The solution in step-(a) may also be prepared by admixing imatinib base, methanesulfonic acid and the solvent medium to obtain a mixture; and heating the mixture to obtain a solution of imatinib mesylate. In one embodiment, the mixture is heated at a temperature of about 40° C. to about 110° C., and more preferably at about 50° C. to about 80° C.

WORKUP

后处理

customThe solution in step-(a) may also be prepared
customthe solvent medium to obtain a mixture
temperatureand heating the mixture

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a4d6e77ffbd24d21a5a697e2ca41ae49
来源数据集: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07947699B2
来源说明: uspto-grants-2011_05

反应 SMILES

[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([NH:21][C:22]([C:24]2[CH:25]=[CH:26][C:27]([CH2:30][N:31]3[CH2:36][CH2:35][N:34]([CH3:37])[CH2:33][CH2:32]3)=[CH:28][CH:29]=2)=[O:23])=[CH:6][C:7]=1[NH:8][C:9]1[N:10]=[CH:11][CH:12]=[C:13]([C:15]2[CH:16]=[CH:17][CH:18]=[N:19][CH:20]=2)[N:14]=1.[CH3:38][S:39]([OH:42])(=[O:41])=[O:40]>>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([NH:21][C:22]([C:24]2[CH:29]=[CH:28][C:27]([CH2:30][N:31]3[CH2:32][CH2:33][N:34]([CH3:37])[CH2:35][CH2:36]3)=[CH:26][CH:25]=2)=[O:23])=[CH:6][C:7]=1[NH:8][C:9]1[N:10]=[CH:11][CH:12]=[C:13]([C:15]2[CH:16]=[CH:17][CH:18]=[N:19][CH:20]=2)[N:14]=1.[CH3:38][S:39]([OH:42])(=[O:41])=[O:40]