1,4-Dioxane hydrochloride → [4-(Hydroxymethyl)piperidin-4-yl]methanol hydrochloride

HRID 550790Notes

Reaction equation

HRID 550790 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][C:11]([CH2:16][OH:17])([CH2:14][OH:15])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:18].O1CCOCC1>CO>[ClH:18].[NH:8]1[CH2:13][CH2:12][C:11]([CH2:16][OH:17])([CH2:14][OH:15])[CH2:10][CH2:9]1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 21955203Tert-butyl 4,4-bis(hydroxymethyl)piperidine-1-carboxylate

Product 1

HCID 67199428[4-(Hydroxymethyl)piperidin-4-yl]methanol hydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of (1-tert-butoxycarbonylpiperidine-4,4-diyl)dimethanol, 4M HCl-dioxane solution, and MeOH was stirred at ambient temperature for 2 hours to yield (piperidine-4,4-diyl)dimethanol hydrochloride.

Sources & evidence

ORD record
ord-e2ba1a8b089941aa9272f123ae43c99b
Source dataset
uspto-grants-2011_05
Patent number
US07947690B2

Reaction notes

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