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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 550790Generated: October 26, 2026

1,4-Dioxane hydrochloride → [4-(Hydroxymethyl)piperidin-4-yl]methanol hydrochloride

https://huagongshe.com/reaction/550790

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,4-Dioxane hydrochlorideHCID 20443148—
ReactantTert-butyl 4,4-bis(hydroxymethyl)piperidine-1-carboxylateHCID 21955203—
SolventMethanolHCID 887—
Product[4-(Hydroxymethyl)piperidin-4-yl]methanol hydrochlorideHCID 67199428—

Reaction Steps

A mixture of (1-tert-butoxycarbonylpiperidine-4,4-diyl)dimethanol, 4M HCl-dioxane solution, and MeOH was stirred at ambient temperature for 2 hours to yield (piperidine-4,4-diyl)dimethanol hydrochloride.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07947690B2
Source datasetuspto-grants-2011_05
ORD IDord-e2ba1a8b089941aa9272f123ae43c99b
Source noteuspto-grants-2011_05