1,4-Dioxane hydrochloride → 4-(3-Hydroxypropyl)piperidin-4-ol hydrochloride

HRID 550791Notes

Reaction equation

HRID 550791 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][C:11]([CH2:15][CH2:16][CH2:17][OH:18])([OH:14])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:19].O1CCOCC1>>[ClH:19].[OH:18][CH2:17][CH2:16][CH2:15][C:11]1([OH:14])[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 21955351HCID 21955351, compound

Product 1

HCID 671972734-(3-Hydroxypropyl)piperidin-4-ol hydrochloride

Procedure

A mixture of 1-tert-butoxycarbonyl-4-(3-hydroxypropyl)piperidin-4-ol and 4M HCl-dioxane solution was stirred at ambient temperature for 3.5 hours to yield 4-(3-hydroxypropyl)piperidin-4-ol hydrochloride.

Sources & evidence

ORD record
ord-a299a5a807ce443b8be497387f7b6085
Source dataset
uspto-grants-2011_05
Patent number
US07947690B2

Reaction notes

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