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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 550791Generated: November 1, 2026

1,4-Dioxane hydrochloride → 4-(3-Hydroxypropyl)piperidin-4-ol hydrochloride

https://huagongshe.com/reaction/550791

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,4-Dioxane hydrochlorideHCID 20443148—
ReactantHCID 21955351HCID 21955351—
Product4-(3-Hydroxypropyl)piperidin-4-ol hydrochlorideHCID 67197273—

Reaction Steps

A mixture of 1-tert-butoxycarbonyl-4-(3-hydroxypropyl)piperidin-4-ol and 4M HCl-dioxane solution was stirred at ambient temperature for 3.5 hours to yield 4-(3-hydroxypropyl)piperidin-4-ol hydrochloride.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07947690B2
Source datasetuspto-grants-2011_05
ORD IDord-a299a5a807ce443b8be497387f7b6085
Source noteuspto-grants-2011_05