Trifluoroacetic acid → 1-[2-Methoxy-1-(3-trifluoromethyl-phenyl)-ethyl]-piperazine trifluoroacetate

HRID 550844Notes

Reaction equation

HRID 550844 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([CH:14]([C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([C:24]([F:27])([F:26])[F:25])[CH:19]=2)[CH2:15][O:16][CH3:17])[CH2:10][CH2:9]1)=O)(C)(C)C.[F:28][C:29]([F:34])([F:33])[C:30]([OH:32])=[O:31]>>[F:28][C:29]([F:34])([F:33])[C:30]([OH:32])=[O:31].[CH3:17][O:16][CH2:15][CH:14]([N:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)[C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([C:24]([F:26])([F:27])[F:25])[CH:19]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 590119454-[2-Methoxy-1-(3-trifluoromethyl-phenyl)-ethyl]-piperazine-1-carboxylic acid tert-butyl ester

Product 1

HCID 866165091-[2-Methoxy-1-(3-trifluoromethyl-phenyl)-ethyl]-piperazine trifluoroacetate

Procedure

A mixture of 4-[2-Methoxy-1 -(3-trifluoromethyl-phenyl)-ethyl]-piperazine-1-carboxylic acid tert-butyl ester (150 mg, 0.387 mmoles) in neat trifluoroacetic acid (3 mL) was stirred at room temperature for one hour. The mixture was concentrated to dryness and pumped on high vacuum to give 1-[2-Methoxy-1-(3-trifluoromethyl-phenyl)-ethyl]-piperazine trifluoroacetate as an oil. The material was used in the next step without further purification.

Workup

  1. concentrationThe mixture was concentrated to dryness

Sources & evidence

ORD record
ord-41fde793a015490e842703454f9fb29b
Source dataset
uspto-grants-2011_05
Patent number
US07947692B2

Reaction notes

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