HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydroxylamine → CH 150
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydroxylamine | HCID 787 | — |
| Reactant | Indole-3-Carboxaldehyde | HCID 10256 | — |
| Reactant | 4-Fluorobenzonitrile | HCID 14517 | — |
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | HCID 178418441 | HCID 178418441 | — |
| Product | CH 150 | HCID 93406 | — |
Reaction Steps
XO-CH145 was prepared by coupling of indole-3-carboaldehyde and 4-fluorobenzonitrile in a similar manner to the third step of the above 1. XO-CH147 was prepared by converting XO-CH145 into a tetrazole derivative using sodium azide, followed by cyanation using hydroxylamine to give XO-CH150 (the following scheme).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07947707B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-cbc315a9f0e844ab8f7c0c93a6e62a53 |
| Source note | uspto-grants-2011_05 |