反应详情

温度

150 °C

To a mixture of 80 g (0.51 mol) of ethyl 1-pyrrolidineacetate and 0.5 g of sodium hydride (in the form of a 60% by weight suspension in mineral oil) was added 48 g (0.54 mol) of 2-(N,N-dimethylamino)ethanol. The mixture was purged with nitrogen gas, heated gradually and then maintained at about 150° C. while collecting the ethanol by-product in a Dean-Stark trap. The liquid reaction product was distilled at 85° C. at a pressure of 100 μmHg to provide 2-(N,N-dimethylamino)-ethyl 1-pyrrolidineacetate. The structure of the product was confirmed by nuclear magnetic resonance and infrared spectral analysis.

1. customThe mixture was purged with nitrogen gas
2. temperatureheated gradually
3. customwhile collecting the ethanol by-product in a Dean-Stark trap
4. customThe liquid reaction product
5. distillationwas distilled at 85° C. at a pressure of 100 μmHg