反应详情

To a solution of 4 g of 1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid hydrochloride in 100 mL of methanol are added dropwise 6 mL of thionyl chloride at room temperature. The reaction mixture is then stirred for 5 hours at room temperature, and then concentrated under reduced pressure. The residue obtained is triturated in 50 mL of ethyl ether and then dried under vacuum at 40° C. 3.22 g of methyl 1H-pyrrolo[2,3-b]pyridine-2-carboxylate hydrochloride are obtained in the form of a pale yellow solid, which is used in unmodified form in the following step.

1. concentrationconcentrated under reduced pressure
2. customThe residue obtained
3. customis triturated in 50 mL of ethyl ether
4. customdried under vacuum at 40° C