Methanol → methyl 1H-pyrrolo[2,3-b]pyridine-2-carboxylate hydrochloride

Participants

Reaction Steps

To a solution of 4 g of 1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid hydrochloride in 100 mL of methanol are added dropwise 6 mL of thionyl chloride at room temperature. The reaction mixture is then stirred for 5 hours at room temperature, and then concentrated under reduced pressure. The residue obtained is triturated in 50 mL of ethyl ether and then dried under vacuum at 40° C. 3.22 g of methyl 1H-pyrrolo[2,3-b]pyridine-2-carboxylate hydrochloride are obtained in the form of a pale yellow solid, which is used in unmodified form in the following step.

Provenance & Evidence