2-Isocyanato-1,4-dimethoxybenzene → 3-{4-[3-(2,5-dimethoxyphenyl)ureido]phenyl}-1H-pyrrolo[2,3-b]pyridine-2-carboxamide

HRID 550922Notes

Reaction equation

HRID 550922 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:16]3[C:11](=[N:12][CH:13]=[CH:14][CH:15]=3)[NH:10][C:9]=2[C:17]([NH2:19])=[O:18])=[CH:4][CH:3]=1.[CH3:20][O:21][C:22]1[CH:27]=[CH:26][C:25]([O:28][CH3:29])=[CH:24][C:23]=1[N:30]=[C:31]=[O:32]>>[CH3:20][O:21][C:22]1[CH:27]=[CH:26][C:25]([O:28][CH3:29])=[CH:24][C:23]=1[NH:30][C:31](=[O:32])[NH:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:16]3[C:11](=[N:12][CH:13]=[CH:14][CH:15]=3)[NH:10][C:9]=2[C:17]([NH2:19])=[O:18])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 41784252-Isocyanato-1,4-dimethoxybenzeneHCID 574453543-(4-aminophenyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxamide

Product 1

HCID 574453143-{4-[3-(2,5-dimethoxyphenyl)ureido]phenyl}-1H-pyrrolo[2,3-b]pyridine-2-carboxamide

Procedure

33.1 mg of yellow lyophilizate 3-{4-[3-(2,5-dimethoxyphenyl)ureido]phenyl}-1H-pyrrolo[2,3-b]pyridine-2-carboxamide are prepared as described in Example 7 starting with 3-(4-aminophenyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxamide and 2,5-dimethoxyphenyl isocyanate.

Sources & evidence

ORD record
ord-efb76eb2e8024c1c98f271e6807bdae2
Source dataset
uspto-grants-2011_05
Patent number
US07947706B2

Reaction notes

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