Trifluoroacetic acid → HCID 59257900, compound

HRID 551055Notes

Reaction equation

HRID 551055 reaction equation
[O:1]=[C:2]1[NH:14][C:12]2[C:13]3[C:5](=[CH:6][N:7]([CH2:15][C:16]([O:18]C(C)(C)C)=[O:17])[C:8]=3[CH:9]=[CH:10][CH:11]=2)[CH2:4][CH2:3]1.C(O)(C(F)(F)F)=O>>[O:1]=[C:2]1[NH:14][C:12]2[C:13]3[C:5](=[CH:6][N:7]([CH2:15][C:16]([OH:18])=[O:17])[C:8]=3[CH:9]=[CH:10][CH:11]=2)[CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86622848HCID 86622848, compound

Product 1

HCID 59257900HCID 59257900, compound

Procedure

To a solution of tert-butyl (5-oxo-3,4,5,6-tetrahydro-1H-azepino[4,3,2-cd]indol-1-yl)acetate from Step D (100 mg, 0.33 mmol) in (1 mL) was added TFA (0.25 mL, 3.3 mmol) and the resulting mixture was stirred at ambient temperature for 1 h. The mixture was concentrated in vacuo to give the title compound. MS: m/z=245 (M+1).

Workup

  1. concentrationThe mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-b985c08bae4c4e39882a0321e3917a07
Source dataset
uspto-grants-2011_05
Patent number
US07947677B2

Reaction notes

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