HCID 86629741, compound → HCID 86629742, compound

HRID 551091Notes

Reaction equation

HRID 551091 reaction equation
[NH2:1][C:2]1[CH:10]=[C:9]([F:11])[CH:8]=[C:7]2[C:3]=1[CH:4]([CH2:13][C:14](OCC)=O)[C:5](=O)[NH:6]2>CC(O)=O>[F:11][C:9]1[CH:8]=[C:7]2[N:6]=[CH:5][CH:4]3[CH:13]=[CH:14][NH:1][C:2]([CH:10]=1)=[C:3]23

Participants

3

Reactant 1

HCID 86629741HCID 86629741, compound

Product 1

HCID 86629742HCID 86629742, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of (±)-ethyl (4-amino-6-fluoro-2-oxo-2,3-dihydro-1H-indol-3-yl)acetate from Step D (3.28 g, 13.0 mmol) in degassed xylenes (100 mL) and AcOH (5 mL) was heated at reflux for 4.5 days, then allowed to slowly cool to ambient temperature. The resulting precipitate was filtered, washing with hexanes, to give the title compound. MS: m/z=207 (M+1).

Workup

  1. temperatureat reflux for 4.5 days
  2. filtrationThe resulting precipitate was filtered
  3. washwashing with hexanes

Sources & evidence

ORD record
ord-5b28ba6e78614a17829a8491f5750790
Source dataset
uspto-grants-2011_05
Patent number
US07947677B2

Reaction notes

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