Ammonia → 4-Fluoro-3-methylbenzamide

HRID 551170Notes

Reaction equation

HRID 551170 reaction equation
[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][C:3]=1[CH3:11].[NH3:12]>C1COCC1>[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH2:12])=[O:7])=[CH:4][C:3]=1[CH3:11]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 27745894-Fluoro-3-methylbenzoyl chloride

Product 1

HCID 27745784-Fluoro-3-methylbenzamide

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

15.70 g (91.0 mmol) 4-fluoro-3-methyl-benzoic acid chloride dissolved in 30 ml THF are added dropwise to 300 ml of conc. ammonia solution and then stirred for 2 hours at ambient temperature. The precipitate formed is filtered off, washed with water and dried.

Workup

  1. customThe precipitate formed
  2. filtrationis filtered off
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-ed137adac40044769300d3da06916c07
Source dataset
uspto-grants-2011_05
Patent number
US07947700B2

Reaction notes

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