HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diphosgene → Methyl 4-isocyanato-3-methylbenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diphosgene | HCID 10426 | — |
| Reactant | Methyl 4-amino-3-methylbenzoate | HCID 2736799 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | Methyl 4-isocyanato-3-methylbenzoate | HCID 86069399 | — |
Reaction Steps
1.50 g (9.08 mmol) methyl 4-amino-3-methyl-benzoate are dissolved in 250 ml dioxane combined with 1.3 ml (10.7 mmol) trichloromethyl-chloroformate and refluxed for 5.5 hours with stirring. Then the mixture is evaporated down i. vac. and the residue is further reacted without any more purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07947700B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-23916c756af34efea3e9d2f190a05587 |
| Source note | uspto-grants-2011_05 |